Structural studies on ebelactone A and B esterase inhibitors produced by Actinomycetes.
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چکیده
منابع مشابه
Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes.
In the course of our studies on enzyme inhibitors produced by microorganisms, two potent esterase inhibitors named ebelactone A and B, were isolated from the cultured broth of the strain MG7-G1 which was closely related to Streptomyces aburaviensis1). They were determined to be new members of mycolic acid /3-lactone. As reported in our previous papers2.3), esterastin, an esterase inhibitor prod...
متن کاملEbelactone, an inhibitor of esterase, produced by actinomycetes.
Sir: We have demonstrated that aminopeptidases, phosphatases and esterases are located not only in cells but also on the cellular membrane of various kinds of animal cells1-3) and that inhibitors of these enzymes modified immune responses4,5). Among these inhibitors, bestatin, amastatin and forphenicine enhanced immune responses, but esterastin which inhibited esterase suppressed immune respons...
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The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
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Biosynthetic pathways of ebelactone A and B were studied by 13C NMR spectroscopy. By using 13C labeled compounds as precursors it was determined that ebelactone A was derived from one molecule of acetic acid and six propionic acids and ebelactone B from one molecule of acetic acid, five propionic acids and one butyric acid.
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The cellulolytic system of the wood-rotting fungus Schizophyllum commune contains an esterase that hydrolyzes methyl ester of 4-O-methyl-d-glucuronic acid. The enzyme, called glucuronoyl esterase, was purified to electrophoretic homogeneity from a cellulose-spent culture fluid. Its substrate specificity was examined on a number of substrates of other carbohydrate esterases such as acetylxylan e...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1982
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.35.1495